Anthropometric measurements, cigarette consumption, and functional activity were recorded. Subjects aged ≥40 years with COPD were enrolled. This study aimed to test the hypothesis by correlation analysis and to identify variables of demographics, symptom scores, images for pulmonary hypertension, lung function, and gas exchange relevant to V D/V TR by multiple regression analysis. It was hypothesized that the V D/V TR was more significant than the standard lung function test in correlation with clinical characteristics and gas exchange (ie, all variables relevant to oxygen and CO 2 tensions and their differences in arterial blood and alveoli) in patients with COPD. 8, 10–15 However, exercise testing is labor consuming and costly and in diseases other than COPD, the V D/V T has been successfully used in non-exercise conditions. The dead space to tidal volume ratio at rest or at peak exercise or change during exercise (V D/V TR, -P, and -C) indicating the severity of ventilation/perfusion (V/Q) mismatch 9 can serve as a marker of physiological change in patients with COPD in a various clinical conditions. 1 Despite mMRC and acute exacerbation being related to the risk assessment of COPD, the power of correlations of FEV 1% with the clinical outcomes is not robust, 2–4 and lung volume such as the residual volume to total lung capacity ratio (RV/TLC) and diffusing capacity measurements (D LCO) provide additional information. The severity of chronic obstructive pulmonary disease (COPD) is usually graded by forced expired volume in one second % predicted (FEV 1%).
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